| Registro completo |
| Provedor de dados: |
BABT
|
| País: |
Brazil
|
| Título: |
Effect of medicinal plants on the parasitemia of Trypanosoma cruzi and on the biodistribution of sodium pertechnetate (Na99mTcO4)
|
| Autores: |
Silva,Roseane Pereira da
Holanda,Cecília Maria de Carvalho Xavier
Barbosa,Vanessa Santos de Arruda
Oliveira,Daniel Pereira de
Lima,Natália Alves
Câmara,Antônia Cláudia Jácome da
Medeiros,Aldo da Cunha
Constantino,Maria Helena Spyrides
|
| Data: |
2008-12-01
|
| Ano: |
2008
|
| Palavras-chave: |
Aloe vera
Artemisia vulgaris
Technetium-99m
Trypanosoma cruzi
Parasitemia
Biodistribution
|
| Resumo: |
Artemisia vulgaris (AV) is an antihelmintic and antimalarial drug; Aloe vera(babosa) acts as antidiabetic, laxative and anti-inflammatory;Benznidazole (BZ) is a trypanocidal of Trypanosoma cruzi (TC). Technetium-99m (99mTc) has been used in nuclear medicine to obtain diagnostic images. This study evaluated the plant effects in TC parasitemia and on the biodistribution of 99mTc in mice. Twenty mice were infected by TC. At the peak of parasitemia, 5 mice received babosa; 5 received AV and 5 received BZ. The parasitemia was determined at 0, 2, 4 and 6 h of drugs administration. Five infected mice without drugs, 5 mice without TC and the group treated with AV, received 99mTc. The radioactivity was calculated. Infected mice that received babosa reduced significantly (p<0.05) the TC parasitemia. The percentage of activity per gram (%ATI/g) decreased significantly on the AV group. These results indicate that babosa possibly is an anti-TC drug and AV reduces the %ATI/g probably due to its biological effects.
|
| Tipo: |
Info:eu-repo/semantics/article
|
| Idioma: |
Inglês
|
| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132008000700034
|
| Editor: |
Instituto de Tecnologia do Paraná - Tecpar
|
| Relação: |
10.1590/S1516-89132008000700034
|
| Formato: |
text/html
|
| Fonte: |
Brazilian Archives of Biology and Technology v.51 n.spe 2008
|
| Direitos: |
info:eu-repo/semantics/openAccess
|
